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当前位置:首页 > 产品中心(Products) > 细胞定制Cell Customization(Cell Customization) > 干细胞(Stem cells) > 神经干细胞(Neural stem cell) > 人ipsc来源的神经干细胞-亨廷顿病患者(CAG50)
  • 人ipsc来源的神经干细胞-亨廷顿病患者(CAG50)

人ipsc来源的神经干细胞-亨廷顿病患者(CAG50)

货号:ST042

价格: ¥询价

规格:
1*10^6cells
数量: - +
  • 人ipsc来源的神经干细胞-亨廷顿病患者(CAG50)
产品描述/Products Description

背景介绍/context:

AcceGen Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, AcceGen NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.


AcceGen NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from AcceGen NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from AcceGen NSCs can be maintained in culture long-term (>1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.

AcceGen人ipsc来源的神经干细胞(NSCs)是在完全确定的神经诱导条件下由无整合诱导的多能干细胞(iPSCs)衍生而来。NSCs表达典型的大脑皮层神经干和祖细胞标志物,如PAX6、FOXG1和nestin,并在培养中作为单层被镀时自发形成极化神经管状玫瑰丛结构(见下)。此外,AcceGen NSCs还能产生一系列脑皮层兴奋性和抑制性神经元,这些神经元具有电活性,并能在体外形成功能性突触和回路。经解冻和电镀后,神经干细胞在40 ~ 50天内最终分化,获得成熟的电生理特性,形成功能突触网络。

AcceGen NSCs很容易区分为神经元或混合神经细胞类型,遵循我们的协议,并使用我们定制的介质和试剂束。根据同步分化协议,AcceGen NSCs可生成高度纯的神经元群。使用我们专门的包衣试剂,从AcceGen神经干细胞中提取的神经元可以在长期培养中维持(1年)。NSCs可以从多个捐赠者那里获得,以满足您的研究需要,并具有广泛的特征。


动物种别/Organism  人

组织来源 Tissue and Cell Type 神经干细胞(NSCs)

形态/Morphology 贴壁生长

 

注意事项:此产品仅供科研使用


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