人脑干星形胶质细胞

星形胶质细胞构成哺乳动物大脑的大部分细胞。它们是类型最多变的，与神经元的所有部分密切相关，因此在它们与神经元的关系中最有趣的功能。它们为神经元提供结构、营养和代谢支持，并调节突触活动。这些星形胶质细胞功能在中风和其他损伤中受损，可严重影响神经元的存活。此外，星形胶质细胞参与了许多神经系统疾病的病理过程。脑损伤后的长期恢复，通过神经突生长、突触可塑性或神经元再生，受到星形细胞表面分子表达和营养因子释放的影响。此外，星形胶质细胞本身的死亡或存活也可能影响最终的临床结果。越来越多的人认识到星形胶质细胞在神经系统功能中的重要性，特别是在调节神经活动方面。我们对星形胶质细胞的了解大多来自体外研究，而星形胶质细胞培养继续为探索这些细胞的不同特性提供了有用的工具。AcceGen研究实验室的HA-bs是从人脑干中分离出来的。在P1代冻存运输。每瓶包含>5×10^5细胞，体积为1ml。用GFAP抗体免疫荧光法对HA-bs进行了表征。HA-bs对HIV-1、HBV、HCV、支原体、细菌、酵母和真菌均检测阴性。在AcceGen研究实验室提供的条件下，HA-bs可达到15倍增，

Astrocytes make up the majority of the cells in the mammalian brain. They are the most variable in type, most intimately associated with all parts of neurons, and thus most functionally interesting in their relationships with neurons. They provide structural, trophic, and metabolic support to neurons and modulate synaptic activity. Impairment of these astrocyte functions during stroke and other insults can critically influence neuron survival. Furthermore, astrocytes have been implicated in the pathological processes of many neurological diseases. Long-term recovery after brain injury, through neurite outgrowth, synaptic plasticity, or neuron regeneration, is influenced by astrocyte surface molecule expression and trophic factor release. In addition, the death or survival of astrocytes themselves may affect the ultimate clinical outcome. Recognition of the importance of astrocytes in nervous system functioning is increasing, specifically regarding the modulation of neural activity. Much of what we have learned about astrocytes is from the in vitro studies and astrocyte cultures are continuing to provide a useful tool in exploring the diverse property of these cells.HA-bs from AcceGen Research Laboratories are isolated from human brain stem. HA-bs are cryopreserved at passage one and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HA-bs are characterized by immunofluorescent method with antibody to GFAP. HA-bs are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HA-bs are guaranteed to further expand for 15 population doublings at the conditions provided by AcceGen Research Laboratories.

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