人真皮微血管内皮细胞

皮肤的血管是由许多细胞和非细胞成分组成的。所有皮肤血管中主要的细胞类型是内皮细胞。内皮细胞形成血管内和血管外腔室之间的界面，并作为细胞和大分子在这两个腔室之间扩散的选择性屏障。皮肤血管内壁的内皮细胞与身体其他部位的内皮细胞具有相同的特征，但它们也表现出一些皮肤特有的特征。它们是各种生理过程的积极参与者。这些包括伤口愈合、止血控制、温度调节和炎症/白细胞运输的调节。内皮细胞的结构和功能在空间和时间上受到不同程度的调节。内皮细胞增殖、静止、凋亡和衰老是使皮肤微血管处于维持和重塑之间的动态平衡的四种主要细胞学状态。AcceGen研究实验室的HDMEC是从人类真皮组织中分离出来的。HDMEC在P1代冷冻保存并运送。每瓶包含>5×10^5细胞，体积为1ml。用抗vWF/因子VIII和CD31 (P-CAM)抗体和摄取DiI-Ac-LDL的免疫荧光法对HDMEC进行了免疫荧光检测。HDMEC对HIV-1、HBV、HCV、支原体、细菌、酵母和真菌均呈阴性。在AcceGen研究实验室提供的条件下，HDMEC细胞可达15倍增。

Blood vessels of the skin are composed of a number of cellular and non-cellular elements. The predominant cell type in all skin blood vessels is the endothelial cell. Endothelial cells form the interface between intravascular and extravascular compartments and serve as a selective barrier for the diffusion of cells and macromolecules between these two compartments. The endothelial cells lining blood vessels of the skin share features of endothelial cells elsewhere in the body, but they also exhibit several skin specific characteristics. They are active participants in a variety of physiological processes. These include wound healing, control of hemostasis, temperature regulation, and the modulation of inflammation/leukocyte trafficking. The structure and function of endothelial cells are differentially regulated in space and time. Endothelial cell proliferation, quiescence, apoptosis, and senescence are the four principal cytologic states that set the cutaneous microvascular in a dynamic balance between maintenance and remodeling.HDMEC from AcceGen Research Laboratories are isolated from human dermal tissue. HDMEC are cryopreserved on passage one and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HDMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CD31 (P-CAM) and by uptake of DiI-Ac-LDL. HDMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HDMEC are guaranteed to further expand for 15 population doublings in the conditions provided by AcceGen Research Laboratories.

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