H157人口腔鳞状上皮癌细胞

由一名84岁男性患者的颊粘膜（20mm-40mm）鳞状细胞癌（SCC）建立。STNMPⅡ期，高分化，淋巴结阳性肿瘤。突变型p53，密码子306外显子8，G至A；野生型K-，N-和Ha-ras。皮下注射和口底注射（原位）在裸鼠体内不致瘤，但皮下形成表皮样囊肿。

动物种别/Organism ： 人类

组织来源 Tissue and Cell Type 口腔黏膜

形态/Morphology  上皮细胞样，贴壁生长

培养基和添加剂/Complete Growth Medium and Culture Conditions：

89%DMEM:F12(MD0600）+2mM谷氨酰胺(SD0007）+10%FBS(SD0200）+0.5 ug/ml氢化可的松钠+G/A(SD0038）

冻存条件：基础培养基+5%DMSO+20%FBS(SD0200)

完全冻存液：免程序降温细胞冻存液（低血清）(SD0001)

注意事项：此产品仅供科研使用

PubMed=1692339; DOI=10.1002/path.1711600313

Prime S.S., Nixon S.V., Crane I.J., Stone A., Matthews J.B., Maitland N.J., Remnant L., Powell S.K., Game S.M., Scully C.

The behaviour of human oral squamous cell carcinoma in cell culture.

J. Pathol. 160:259-269(1990)

PubMed=1744799; DOI=10.1002/path.1711650208

Mutlu S., Matthews J.B., Midda M., Scully C., Prime S.S.

MHC antigen expression in human oral squamous carcinoma cell lines.

J. Pathol. 165:129-136(1991)

PubMed=7633286; DOI=10.1016/0964-1955(94)00030-8

Yeudall W.A., Paterson I.C., Patel V., Prime S.S.

Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.

Eur. J. Cancer B Oral Oncol. 31:136-143(1995)