人永生化神经干细胞- L-Myc (LM-NSC008)

背景介绍/context：

The Immortalised Human Neural Stem Cells – L-myc (LM-NSC008) were obtained from fetal brain tissue. After stem cell isolation and propagation, the primary cells were Immortalised by transduction with retrovirus carrying the L-myc gene. The Immortalised Human Neural Stem Cells – L-myc (LM-NSC008) retain the important phenotype of the parental Neural Stem Cells after differentiation such as the expression of neuronal class III b-TUBULIN, astroglial markers SOX9 and GFAP, and oligodendrocyte marker O4, which coincided with neuronal, astrocytic, and oligodendroglial morphologies. The cells show normal karyotype in vitro and did not show abnormal growth or tumorigenicity in vitro. The Immortalised Human Neural Stem Cells – L-myc (LM-NSC008) is a valuable tool for research focusing on CNS diseases.

人永生化神经干细胞L-myc (LM-NSC008)取自胎儿脑组织。原代细胞经分离繁殖后，经携带L-myc基因的逆转录病毒转导获得永生。使人类神经干细胞L-myc (LM-NSC008)保留的重要表型父母的神经干细胞分化后神经元的表达第三类b-TUBULIN等astroglial标记SOX9, GFAP和少突细胞标记O4,恰逢神经元,星形,oligodendroglial形态。这些细胞在体外表现出正常的核型，没有表现出异常的生长和致瘤性。永生化的人类神经干细胞L-myc (LM-NSC008)是研究中枢神经系统疾病的一个有价值的工具。

动物种别/Organism  人

组织来源 Tissue and Cell Type 脑组织

形态/Morphology 贴壁生长 

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