人支气管上皮细胞系（BEAS-2B）

背景介绍/context：

BEAS-2B cells were derived from normal bronchial epithelium obtained from autopsy of non-cancerous individuals. Cells were infected with a replication-defective SV40/adenovirus 12 hybrid and cloned. Squamous differentiation can be observed in response to serum. This ability can be used for screening chemical and biological agents inducing or affecting differentiation and/or carcinogenesis. The cell line has been applied for studies of pneumococcal infection mechanisms. BEAS-2B was described to express keratins and SV40 T antigen. Subculturing the cells before confluency is necessary as confluent cultures rapidly undergo squamous terminal differentiation.

BEAS-2B细胞来自于正常支气管上皮，这些上皮来自于未癌变个体的尸检。细胞被复制缺陷SV40/腺病毒12杂交体感染并克隆。在血清中可以观察到鳞状分化。这种能力可用于筛选诱导或影响分化和/或致癌的化学和生物制剂。该细胞系已应用于肺炎球菌感染机制的研究。BEAS-2B表达角蛋白和sv40t抗原。融合前的细胞传代是必要的，因为融合培养迅速发生鳞状终末分化。

动物种别/Organism  人

组织来源 Tissue and Cell Type 支气管

形态/Morphology 上皮细胞样，贴壁生长 

注意事项：此产品仅供科研使用