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产品描述/Products Description
背景介绍/context：
H6c7 is an immortalized epithelial cell line derived from normal human pancreatic duct epithelial (HPDE) cells. This cell line is an attractive model for human pancreatic duct cell carcinogenesis studies.
Highlights
Demonstrate near normal genotype and phenotype of HPDE cellsDisplay copy number of p16INK4A gene, wild type p53 and KRAS genesMorphologically similar to the primary HPDE cells, grow anchorage-dependently and do not form tumors in scid miceGrowth remains inhibited by transforming growth factor (TGF)-beta 1。
H6c7是一种来源于正常人胰腺导管上皮细胞(HPDE)的永生化上皮细胞系。该细胞系是一个有吸引力的模型，以人类胰管细胞的癌变研究。
突出显示，在scid细胞中，HPDE细胞接近正常基因型和表型，显示p16INK4A基因拷贝数，野生型p53和KRAS基因形态与原代HPDE细胞相似，依赖于固定生长，不形成肿瘤，生长仍然受到转化生长因子(TGF)- 1的抑制。
动物种别/Organism 人
组织来源 Tissue and Cell Type 胰腺导管上皮细胞
形态/Morphology 上皮细胞样，贴壁生长
注意事项：此产品仅供科研使用
